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HLA-B27 gene

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HLA-B27 gene

Research has shown that most people who have ankylosing spondylitis carry a particular gene known as human leukocyte antigen B27 (HLA-B27). Among people with ankylosing spondylitis, 9 out of 10 have HLA-B27.

It is thought that having HLA-B27 may make having ankylosing spondylitis more likely. However, if you have the gene it does not necessarily mean that you will also have the condition. It is estimated that 8 in 100 people in the general population have the HLA-B27 gene but do not have ankylosing spondylitis.

Ankylosing spondylitis can run in families, and the HLA-B27 gene can be inherited (passed on) from another family member.

Definition from NHS Choices: HLA-B27 gene

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