Text Search

Theme Search

  • 1
  • 2
  • 3
  • 4

HLA-B27 gene

Search for glossary terms (regular expression allowed)
Begin with Contains Exact termSounds like
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Term Definition
HLA-B27 gene

Research has shown that most people who have ankylosing spondylitis carry a particular gene known as human leukocyte antigen B27 (HLA-B27). Among people with ankylosing spondylitis, 9 out of 10 have HLA-B27.

It is thought that having HLA-B27 may make having ankylosing spondylitis more likely. However, if you have the gene it does not necessarily mean that you will also have the condition. It is estimated that 8 in 100 people in the general population have the HLA-B27 gene but do not have ankylosing spondylitis.

Ankylosing spondylitis can run in families, and the HLA-B27 gene can be inherited (passed on) from another family member.

Definition from NHS Choices: HLA-B27 gene

Tell us your story

We are always looking for new stories to add to this site, and are particularly keen to hear from more practitioners. Your colleagues can learn so much from how you’ve dealt with situations which involved genetics.

Contact Us

Tell us what you think

Your feedback is important in helping us to enhance this website. Please take a moment to complete the brief questionnaire.


Winners of the Association of Healthcare Communicators Best use of new media award 2009.
‘This was superb’ - Judge’s comment.


Betsi Cadwaladr Scholarship Foundation Joint Award Winners 2013.

Betsi Cadwaladr logo